Cardiovascular disease risk factors in HIV patients -association with antiretroviral therapy. Results from the DAD study
Identifieur interne : 00B258 ( Main/Exploration ); précédent : 00B257; suivant : 00B259Cardiovascular disease risk factors in HIV patients -association with antiretroviral therapy. Results from the DAD study
Auteurs : Nina Friis-M Ller [Danemark] ; Rainer Weber [Suisse] ; Peter Reiss [Pays-Bas] ; Rodolphe Thiebaut [France] ; Ole Kirk [Danemark] ; Antonella D'Arminio Monforte [Italie] ; Christian Pradier [France] ; Linda Morfeldt [Suède] ; Silvia Mateu [Espagne] ; Matthew Law [Australie] ; Wafaa El-Sadr [États-Unis] ; Stephan De Wit [Belgique] ; Caroline A. Sabin [Royaume-Uni] ; Andrew N. Phillips [Royaume-Uni] ; Jens D. Lundgren [Danemark]Source :
- AIDS : (London) [ 0269-9370 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Objective: To determine the prevalence of risk factors for cardiovascular disease (CVD) among HIV-infected persons, and to investigate any association between such risk factors, stage of HIV disease, and use of antiretroviral therapies. Design: Baseline data from 17852 subjects enrolled in DAD, a prospective multinational cohort study initiated in 1999. Methods: Cross-sectional analyses of CVD risk factors at baseline. The data collected includes data on demographic variables, cigarette smoking, diabetes mellitus, hypertension, dyslipidaemia, body mass index, stage of HIV infection, antiretroviral therapy. Results: Almost 25% of the study population were at an age where there is an appreciable risk of CVD, with those receiving a protease inhibitor (PI) and/or non-nucleoside reverse transcriptase inhibitor (NNRTI) tending to be older. 1.4% had a previous history of CVD and 51.5% were cigarette smokers. Increased prevalence of elevated total cholesterol (≥ 6.2 mmol/l) was observed among subjects receiving an NNRTI but no PI [odds ratio (OR), 1.79; 95% confidence interval (Cl), 1.45-2.22], PI but no NNRTI (OR, 2.35; 95% Cl, 1.92-2.87), or NNRTI + PI (OR, 5.48; 95% Cl, 4.34-6.91) compared to the prevalence among antiretroviral therapy (ART)-naive subjects. Subjects who have discontinued ART as well as subjects receiving nucleoside reverse transcriptase inhibitors had similar cholesterol levels to treatment-naive subjects. Higher CD4 cell count, lower plasma HIV RNA levels, clinical signs of lipodystrophy, longer exposure times to NNRTI and PI, and older age were all also associated with elevated total cholesterol level. Conclusion: HIV-infected persons exhibit multiple known risk factors for CVD. Of specific concern is the fact that use of the NNRTI and PI drug classes (alone and especially in combination), particularly among older subjects with normalized CD4 cell counts and suppressed HIV replication, was associated with a lipid profile known to increase the risk of coronary heart disease.
Affiliations:
- Australie, Belgique, Danemark, Espagne, France, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Aquitaine, Catalogne, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, Svealand, État de New York
- Amsterdam, Barcelone, Bordeaux, Bruxelles, Copenhague, Londres, Milan, Nice, Stockholm, Sydney
- Université d'Amsterdam
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Results from the DAD study</title><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Swiss HIV Cohort Study (SHCS), Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich</s1><s2>Zurich</s2><s3>CHE</s3><sZ>2 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>ATHENA, Department of Medicine and Infectious Diseases, Academic Medical Center, University of Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Aquitaine, Institut de Santé Publique, d'Epidémiologie et de Développement - Inserm U330, Bordeaux University Hospital</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>EuroSIDA, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>ICONA, Department of Infectious Diseases, L Sacco Hospital, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Nice Cohort, Service des Maladies Infectieuses et Tropicales et Medicine Interne, C.H.U. Nice Hopital de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>HivBivus, Department of Infectious Diseases, Karolinska Hospital</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Mateu, Silvia" sort="Mateu, Silvia" uniqKey="Mateu S" first="Silvia" last="Mateu">Silvia Mateu</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>BASS, Department of Clinical Pharmacology and Therapeutics, Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>AHOD, National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>CPCRA, Division of Epidemiology, Columbia University School of Public Health</s1><s2>New York</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Brussels St. Pierre Cohort, Department of Infectious Diseases, C.H.U. Saint Pierre Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>12 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0407501</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0407501 INIST</idno><idno type="RBID">Pascal:03-0407501</idno><idno type="wicri:Area/PascalFrancis/Corpus">005260</idno><idno type="wicri:Area/PascalFrancis/Curation">000E66</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">005047</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">005047</idno><idno type="wicri:doubleKey">0269-9370:2003:Friis M Ller N:cardiovascular:disease:risk</idno><idno type="wicri:Area/Main/Merge">00C032</idno><idno type="wicri:Area/Main/Curation">00B258</idno><idno type="wicri:Area/Main/Exploration">00B258</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cardiovascular disease risk factors in HIV patients -association with antiretroviral therapy. Results from the DAD study</title><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Swiss HIV Cohort Study (SHCS), Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich</s1><s2>Zurich</s2><s3>CHE</s3><sZ>2 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>ATHENA, Department of Medicine and Infectious Diseases, Academic Medical Center, University of Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Aquitaine, Institut de Santé Publique, d'Epidémiologie et de Développement - Inserm U330, Bordeaux University Hospital</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>EuroSIDA, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>ICONA, Department of Infectious Diseases, L Sacco Hospital, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Nice Cohort, Service des Maladies Infectieuses et Tropicales et Medicine Interne, C.H.U. Nice Hopital de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>HivBivus, Department of Infectious Diseases, Karolinska Hospital</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Mateu, Silvia" sort="Mateu, Silvia" uniqKey="Mateu S" first="Silvia" last="Mateu">Silvia Mateu</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>BASS, Department of Clinical Pharmacology and Therapeutics, Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>AHOD, National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>CPCRA, Division of Epidemiology, Columbia University School of Public Health</s1><s2>New York</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Brussels St. Pierre Cohort, Department of Infectious Diseases, C.H.U. Saint Pierre Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>12 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Antiviral</term><term>Cardiovascular disease</term><term>Chemotherapy</term><term>Clinical stage</term><term>Human</term><term>Risk factor</term><term>Toxicity</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Appareil circulatoire pathologie</term><term>SIDA</term><term>Facteur risque</term><term>Traitement</term><term>Chimiothérapie</term><term>Antiviral</term><term>Toxicité</term><term>Stade clinique</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine the prevalence of risk factors for cardiovascular disease (CVD) among HIV-infected persons, and to investigate any association between such risk factors, stage of HIV disease, and use of antiretroviral therapies. Design: Baseline data from 17852 subjects enrolled in DAD, a prospective multinational cohort study initiated in 1999. Methods: Cross-sectional analyses of CVD risk factors at baseline. The data collected includes data on demographic variables, cigarette smoking, diabetes mellitus, hypertension, dyslipidaemia, body mass index, stage of HIV infection, antiretroviral therapy. Results: Almost 25% of the study population were at an age where there is an appreciable risk of CVD, with those receiving a protease inhibitor (PI) and/or non-nucleoside reverse transcriptase inhibitor (NNRTI) tending to be older. 1.4% had a previous history of CVD and 51.5% were cigarette smokers. Increased prevalence of elevated total cholesterol (≥ 6.2 mmol/l) was observed among subjects receiving an NNRTI but no PI [odds ratio (OR), 1.79; 95% confidence interval (Cl), 1.45-2.22], PI but no NNRTI (OR, 2.35; 95% Cl, 1.92-2.87), or NNRTI + PI (OR, 5.48; 95% Cl, 4.34-6.91) compared to the prevalence among antiretroviral therapy (ART)-naive subjects. Subjects who have discontinued ART as well as subjects receiving nucleoside reverse transcriptase inhibitors had similar cholesterol levels to treatment-naive subjects. Higher CD4 cell count, lower plasma HIV RNA levels, clinical signs of lipodystrophy, longer exposure times to NNRTI and PI, and older age were all also associated with elevated total cholesterol level. Conclusion: HIV-infected persons exhibit multiple known risk factors for CVD. Of specific concern is the fact that use of the NNRTI and PI drug classes (alone and especially in combination), particularly among older subjects with normalized CD4 cell counts and suppressed HIV replication, was associated with a lipid profile known to increase the risk of coronary heart disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Catalogne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Londres</li><li>Milan</li><li>Nice</li><li>Stockholm</li><li>Sydney</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name></region><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name></country><country name="Suisse"><noRegion><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name></region><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name></country><country name="Italie"><region name="Lombardie"><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Mateu, Silvia" sort="Mateu, Silvia" uniqKey="Mateu S" first="Silvia" last="Mateu">Silvia Mateu</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name></region></country><country name="États-Unis"><region name="État de New York"><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name></region><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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